Experimental periodontitis promotes transient vascular inflammation and endothelial dysfunction

Vascular Inflammation and Endothelial Dysfunction in Experimental Hypertension

Essential hypertension is characterized by increased peripheral vascular resistance to blood flow. The endothelium is a crucial regulator of vascular tone. Its function is impaired in patients with hypertension, with reduced vasodilation, increased vascular tone associated with a proinflammatory and prothrombotic state. Low-grade inflammation localized in vascular tissue is therefore recognized...

Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis

Signalling pathways that control endothelial cell (EC) permeability, leukocyte adhesion and inflammation are pivotal for atherosclerosis initiation and progression. Here we demonstrate that the Sterile-20-like mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), which has been implicated in inflammation, is abundantly expressed in ECs and in atherosclerotic plaques from mice and hu...

Vascular inflammation and endothelial dysfunction in fracture healing.

Angiogenesis is an important step in bone fracture healing. In this article, we report on the healing of long bone fractures, and the involvement of the vascular and the inflammatory systems in the process. We conducted a prospective study of 20 healthy adults with traumatic long bone fracture. One week after fracture, and then 1 month later, we evaluated markers of inflammation: vascular respo...

Endothelial Dysfunction and Inflammation

Inflammation, Endothelial Dysfunction, and Thromboembolism.

Inflammatory mechanisms are intimately tied up with direct defense against infection, immunity, and healing. In order for processes to proceed at affected sites within tissues, capillary walls have to be able to modify their permeability to soluble mediators, particles, and cells. These systems are in a delicate balance, which can be easily disrupted, giving rise to exacerbating diseases or dys...